Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii
نویسندگان
چکیده
منابع مشابه
Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.
Cancer is a general name for more than 100 malignant diseases. It is postulated that all cancers start from a single abnormal cell that grows out of control. Untreated cancers can cause serious consequences and deaths. Great progress has been made in cancer research that has significantly improved our knowledge and understanding of the nature and mechanisms of the disease, but the origins of ca...
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The gene for the enzyme dolichol phosphate mannose (Dol-P-Man) synthase from the parasitic protozoan Trypanosoma brucei brucei (T. brucei) was cloned by screening a T. brucei cDNA library and then sequenced. The library was constructed in a yeast expression vector and the positive clone was identified by complementation of a temperature-sensitive defect in the yeast strain DPM 1-6 [Orlean, Albr...
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Protein synthesis in Trypanosoma brucei brucei was rapidly inhibited during polyamine depletion by DL-adifluoromethylornithine (DFMO) in vitro and in vivo. [3H]Leucine incorporation was depressed 30-40 % by 24 h and 80-90 % by 48 h of DFMO treatment. Concomitantly there was an apparent decrease in the synthesis of the variant-specific glycoprotein (VSG) in DFMO-treated trypanosomes, as measured...
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The mitochondrial inner and outer membranes are composed of a variety of integral membrane proteins, assembled into the membranes post-translationally. The smallTIMs are a group of ~10 kDa proteins that function as chaperones to ferry importedmembrane proteins across the mitochondrial intermembrane space. In yeast there arefive small TIM proteins: Tim8, Tim9, Tim10, Tim12 and Tim13,...
متن کاملMethods for parasitic protozoans detection in the environmental samples.
The environmental route of transmission of many parasitic protozoa and their potential for producing large numbers of transmissive stages constitute persistent threats to public and veterinary health. Conventional and new immunological and molecular methods enable to assess the occurrence, prevalence, levels and sources of waterborne protozoa. Concentration, purification, and detection are the ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1502599112